| # | Pitcher | Team | Opp | Pts | Range | K | IP | ER | H | BB | W% | L% | O/U | Venue | Time | Status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Joe Ryan | MIN | @ TEX | 14.8 | 9–21 | 6.9 | 6.3 | 2.8 | 4.6 | 1.6 | 31% | 29% | 7.5 | Globe Life Field | 6:35 PM | FA |
| 2 | Bryan Woo | SEA | vs BAL | 14.2 | 9–20 | 6.0 | 5.8 | 2.4 | 4.0 | 1.4 | 34% | 25% | 7.5 | T-Mobile Park | 8:10 PM | FA |
| 3 | Ryan Weathers | NYY | vs CWS | 12.9 | 7–19 | 5.5 | 5.9 | 2.5 | 4.3 | 2.1 | 34% | 25% | 9.5 | Yankee Stadium | 11:05 PM | FA |
| 4 | Trey Yesavage | TOR | @ BOS | 12.2 | 6–18 | 6.4 | 5.7 | 2.3 | 4.0 | 2.4 | 27% | 33% | 8.5 | Fenway Park | 5:35 PM | FA |
| 5 | Gage Jump | OAK | vs LAA | 11.5 | 6–18 | 5.8 | 6.1 | 3.1 | 4.9 | 2.3 | 32% | 28% | 10 | Sutter Health Park | 1:40 AM | FA |
| 6 | Sonny Gray | BOS | vs TOR | 11.4 | 6–17 | 4.8 | 5.7 | 2.4 | 4.6 | 1.4 | 31% | 29% | 8.5 | Fenway Park | 5:35 PM | FA |
| 7 | Shane Baz | BAL | @ SEA | 10.5 | 5–17 | 5.8 | 6.1 | 3.0 | 4.9 | 2.3 | 24% | 37% | 7.5 | T-Mobile Park | 8:10 PM | FA |
| 8 | Noah Cameron | KC | vs STL | 10.3 | 5–16 | 4.5 | 5.6 | 2.4 | 4.5 | 1.9 | 30% | 30% | 9 | Kauffman Stadium | 11:40 PM | FA |
| 9 | Shane Drohan | MIL | vs CLE | 9.8 | 4–15 | 4.2 | 4.7 | 1.9 | 3.4 | 2.1 | 34% | 25% | 7.5 | American Family Field | 6:10 PM | FA |
| 10 | Jack Leiter | TEX | vs MIN | 9.6 | 4–15 | 4.8 | 5.3 | 2.4 | 4.0 | 2.1 | 27% | 33% | 7.5 | Globe Life Field | 6:35 PM | FA |
| 11 | Parker Messick | CLE | @ MIL | 9.4 | 4–15 | 4.3 | 5.4 | 2.2 | 4.6 | 1.7 | 24% | 37% | 7.5 | American Family Field | 6:10 PM | FA |
| 12 | Aaron Nola | PHI | vs NYM | 9.2 | 3–15 | 4.6 | 5.0 | 2.6 | 4.2 | 1.6 | 31% | 29% | 9.5 | Citizens Bank Park | 10:40 PM | FA |
| 13 | Martín Pérez | ATL | vs SF | 9.2 | 4–15 | 3.6 | 5.2 | 2.4 | 4.6 | 2.1 | 32% | 27% | 8 | Truist Park | 11:15 PM | FA |
| 14 | Matthew Liberatore | STL | @ KC | 7.9 | 3–13 | 3.1 | 4.7 | 2.1 | 4.0 | 1.2 | 28% | 32% | 9 | Kauffman Stadium | 11:40 PM | FA |
| 15 | Landen Roupp | SF | @ ATL | 7.7 | 2–14 | 4.1 | 5.0 | 2.3 | 4.2 | 2.1 | 25% | 35% | 8 | Truist Park | 11:15 PM | FA |
| 16 | Sean Manaea | NYM | @ PHI | 7.7 | 2–14 | 4.1 | 4.0 | 1.9 | 3.2 | 1.3 | 27% | 33% | 9.5 | Citizens Bank Park | 10:40 PM | FA |
| 17 | Sean Burke | CWS | @ NYY | 7.1 | 1–14 | 5.2 | 5.1 | 3.1 | 4.3 | 3.0 | 26% | 35% | Yankee Stadium | 11:05 PM | FA |
